The U.P. fits mountain bike tires up to 2.1” wide. But you can also fit a 40mm cross tire, or a 28mm road tire, or anything else in-between (exact tire sizes depend on manufacturing tolerances and rim width, so this is a guideline. Always make sure you have 6mm clearance between tire and frame).
How do we fit such a wide range of tires without affecting the handling? Let's start with the numbers; below is the outside radius for various wheel+tire combos:
As you can see, the top-4 wheel+tire combos (700c cross/road tires and 650b mountain bike tire) are very close in radius, the bottom one (the 29er mountain bike tire) is way off.
So you’ll hardly notice a difference in geometry swapping 700c cross/road and 650b mountain bike tires on the U.P., while 29er tires would make a total mess of the handling.
There is a second reason we designed for 650b and not 29er tires. They would require very long chainstays, while the U.P. now sports a very short 420mm rear end. Most gravel and cross bikes have longer chainstays than that yet they can't fit anywhere near the same size of tire.